Interpretation of arterial blood gas pubmed central pmc. Developed by schwartz and relman, 18 this approach, entirely based on the hendersonhasselbalch equation, predicts the nature of acidbase disorders. Many methods exist to guide the interpretation of the abg. Interpreting acid base disorders is an essential nursing skill that involves a three step process. Acidbase homeostasis is fundamental for maintaining life. Acid base 15,000 mmol of co2 generates h2co2 and 50100 meq of nonvolatile acid mostly sulfuric from sulfurcontaining amino acids are made balance is maintained by normal pulmonary and renal excretion of these acids. Interpreting acidbase disorders is an essential nursing skill that involves a three step process. Now in its sixth edition, basic skills has been expanded and updated to cover new drugs, research, and therapeutic approaches.
Acid base balance an overview sciencedirect topics. This discussion does not include some methods, such as analysis of base excess or stewarts strong ion difference. Understanding acidbase disorders a four step approach in order to understand the nature of an acidbase problem, we recommend a structured approach during which the following four questions should be asked. Accurate and timely interpretation of an acid base disorder can be lifesav ing, but the establishment of a correct diagnosis may be challenging. Acid base disorders are very common clinical problems. An introduction to acidbase disorders and interpretation. Ryan killian, pharmd, bcps assistant professor clinical pharmacy. The pco2 varies directly with ventilation, and is the primary abnormality in the respiratory acid base disorders. Thus, it is important when evaluating acidbase disorders to determine whether changes in p co 2 and hco 3. The primary disorder leads to a change in ph, while compensatory changes attempt to normalize the hco 3. Open access full text article facing acidbase disorders in. Learning objectives the clinician after participating in the roundtable will be able to.
Among the many intellectual challenges encountered by medical students, residents, and practitioners, that of interpreting clinical acid base disorders remains one of the most difficult challenges to master. There are other clues and diagnoses which should be obvious in the case. Basic skills in interpreting laboratory data continues to be the most popular teaching text on laboratory data for pharmacy students as well as the goto reference for pharmacists in therapeutic practice. Diagnosis is made by arterial blood gas interpretation. Arterial blood gas primer clinical respiratory diseases. When the respiratory and renal systems are working together, they are able to keep the blood ph balanced by maintaining 1 part acid to 20 parts base. These indicators will allow you to determine the type of disorder. He saw the need for this textbook, had the vision to create the first. An introduction to acidbase disorders and interpretation of. Jun 04, 2014 moreover, a sizable number of intensivecare physicians experience difficulties in interpreting the significance of or understanding the etiology of certain forms of acidbase disequilibria. This short book is an attempt to lead the uninitiated and the timid to an understanding of.
This episode of crackcast covers rosens chapter 124, acid base disorders. Skill in interpreting biochemical data to correctly identify and treat acidbase disorders is an essential competency for clinicians. Facing acidbase disorders in the third millennium the. Acidbase disturbances cleveland clinic journal of medicine. In a perfect world complete information about a patient is available before acid base values are analyzed. Acutechronic phase only with respiratory disorders. These conditions can be categorized as acidoses or alkaloses and have a respiratory or metabolic origin, depending on the cause of the imbalance. However, the final interpretation of an acid base disorder is based on biological data issued from blood samples tools which allow to move on step by step. Open access full text article facing acidbase disorders. This will be the only video you will need to interpret your abgs. A thorough understanding of acidbase balance is mandatory for any physician, and intensivist, and the.
Aug 29, 2017 the history of the patient, the context, and clinical signs are essential to diagnose an acid base disorder. Familiarity with obtaining and interpreting blood gases can be essential in the management of these patients. He saw the need for this textbook, had the vision to create the first edition, and edited the second edition. The primary causes of acid base disturbances are abnormalities in the respiratory system and in the metabolic or renal system. An interesting finding of this abg is that one may. Simple acidbase disorders are caused by the four primary acidbase disturbances, metabolic or respiratory in origin, with an anticipated compensatory change9 table 1. Acidbase disorders knowledge for medical students and. Acidbase balance, fruit and vegetable intakes, and bone health. Acidbase balance may play a role in calcium retention and thus bone health. Acid base disorders made so easy even a caveman can do it lorraine r franzi, mshsm, rd, ldn, cnsd nutrition support specialist university of pittsburgh medical center pittsburgh, pa i. Among the many intellectual challenges encountered by medical students, residents, and practitioners, that of interpreting clinical acidbase disorders remains one of the most difficult challenges to master. A lecture discussing the phenomenon of physiologic compensation for derangements of acidbase balance, and how to use an understanding of. Base excess was developed in the 1960s by siggaardandersen 10 in denmark and later refined to the plasma or standard base excess for. Acidbase 15,000 mmol of co2 generates h2co2 and 50100 meq of nonvolatile acid mostly sulfuric from sulfurcontaining amino acids are made balance is maintained by normal pulmonary and renal excretion of these acids.
In their article a patient with altered mental status and an acidbase disturbance, 1 drs. Acidosis is caused by a decrease in the sid but an increase in the total weak acid. Abcs of abgs a guide to interpreting acid base disorders. Jan 31, 2012 a lecture discussing the phenomenon of physiologic compensation for derangements of acid base balance, and how to use an understanding of compensation to identify the presence of mixed acid base. Traditional tools for interpreting acidbase disorders may not be adequate for analyzing the complex nature of these metabolic abnormalities. In these mixed disorders, values may be deceptively normal.
The first step in interpreting an acidbase problem is to look at. Ebscohost serves thousands of libraries with premium essays, articles and other content including abcs of abgs. Acidosis and alkalosis are used to describe how the ph changes. I am going to present a structured approach to the identification of acidbase disorders based on a set of welldefined rules. How to interpret arterial blood gas results correspondence. Shownotes pdf here key point patients with an acute severe metabolic acidosis rely on a robust respiratory compensation. We use the physiological approach2,4 as a simple and serviceable method applicable to patients with compromised renal function in the critical care setting. Acid base balance disorders can be found in a primary or secondary form in patients with a disease process such as diabetes mellitus or acute renal failure, among others. Acid base pathophysiology can be separated into metabolic or respiratory acidosis and alkalosis, as well as those disturbances that are compensated.
Acidbase disorders msd manual professional edition. What follows is a logical framework for looking at acid base values with no patient. Acid base, boy bands, and grandfather clocks with joel. Disorders of acidbase balance can create complications in many disease states, and occasionally the abnormality may be so severe so as to become a lifethreatening risk factor. Rutecki state that 5oxoproline or pyroglutamic acidosis is associated with an elevated osmol gap. In addition, you will find tables that list commonly encountered acid base disorders. Fluids, electrolytes, acidbase disorders, and nutrition support. The content of the open access version may differ from that of the licensed version. You are watching an educational video about interpreting abgs. An introduction to acidbase disorders and interpretation of blood gases blood gasesacidbase. What follows is a logical framework for looking at acidbase values with no patient. The following sixstep process helps ensure a complete interpretation of every abg.
This article provides readers with a stepwise approach for assessing abgs, as well as offering actual case examples to familiarize the reader with the concepts of acidbase disorders. Fluids, electrolytes, acidbase disorders, and nutrition support roland n. The hco3 concentration is regulated by the kidney, and is the primary abnormality in the metabolic acidbase disturbances discussed below. Fluids, electrolytes, acidbase disorders, and nutrition. Introduction disorders of acidbase balance can be found in as many as nine of every 10 patients in the icu, which means that acidbase disorders may be the most common clinical problems you will encounter in the icu. Acidbase balance disorders can be found in a primary or secondary form in patients with a disease process such as diabetes mellitus or acute renal failure, among others. Moreover, a sizable number of intensivecare physicians experience difficulties in interpreting the significance of or understanding the etiology of certain forms of acidbase disequilibria. How to interpret acid base disorders acid base imbalances. Paco 2 decreases, and pao 2 increases in pregnancy the key feature of gas exchange in pregnancy is the increased metabolic rate of the combined motherfoetus organism, with a resulting increase in the total o 2 consumption and co 2 production.
Apr 21, 2019 arterial blood gas analysis is used to determine the adequacy of oxygenation and ventilation, assess respiratory function and determine the acidbase balance. Jun 08, 2011 this was the most singularly helpful thing i read to help me with acid base disorders at least with a traditional nonstewart understanding of them. This primer describes a clinical approach to interpreting arterial blood gases. When interpreting acidbase status, it is important always to take the clinical context into account. Analyzing acid base data with no patient is a like bidding a bridge hand with no partner. Sulfurcontaining amino acids in meat and cereals are oxidized in the liver and also lower blood ph.
A guide to interpreting acid base disorders is the major driving force for increase in ph. The authors assume little knowledge of the topic on behalf of the reader, and begin with some basic definitions of an acid, a base and a buffer, before introduction of the allimportant hendersonhasselbalch equation that defines the relationship between ph, bicarbonate and pco 2. Waddell, dvm, diplomate acvecc this article is the first in a 2part series that addresses alterations in acidbase and respiratory function, which are common in both emergency patients as well as hospitalized, critically ill patients. Acidbase disorders made so easy even a caveman can do it lorraine r franzi, mshsm, rd, ldn, cnsd nutrition support specialist university of pittsburgh medical center pittsburgh, pa i. Master the 5 steps for interpreting acidbase disorders and decode any abg, vbg, and bmp to find the primary disorder, and any other disorders tucked away in the abg. Analysis of the arterial blood gave the following values. It is, therefore, important that students and physicians be able to interpret the results of arterial blood gas sampling, determine the patients acid base status and assess the adequacy of oxygenation. This article provides readers with a stepwise approach for assessing abgs, as well as offering actual case examples to familiarize the reader with the concepts of acid base disorders. There is an open access version for this licensed article that can be read free of charge and without license restrictions. These data provide information regarding potential primary and compensatory processes that affect the bodys acid base buffering system. Analyzing acidbase data with no patient is a like bidding a bridge hand with no partner. Many tools for interpreting acidbase disorders have been developed. This was the most singularly helpful thing i read to help me with acid base disorders at least with a traditional nonstewart understanding of them. The cited reference by tan et al 2 describes a patient who most likely had ketoacidosis, perhaps complicated by isopropyl alcohol.
A guide to interpreting acidbase disorders is the major driving force for increase in ph. Complex or mixed acidbase disturbances involve more than one primary process. Arterial blood gas analysis is used to determine the adequacy of oxygenation and ventilation, assess respiratory function and determine the acid base balance. Of metabolic acid base status the standard base excess calculation10,11 has been inconsistently used for acid base analysis in the united states, but it is widely used in the rest of the world. Acidbase pathophysiology can be separated into metabolic or respiratory acidosis and alkalosis, as well as those disturbances that are compensated. For example, if presented with abg results showing a normal ph, low paco2 and low hco3. As usual, an irresponsibly long digression follows. Physiological approach to assessment of acid base disturbances. However, the final interpretation of an acidbase disorder is based on biological data issued from blood samples tools which allow to move on step by step. Medhub is a webbased residency management system designed to track and document a variety of program and resident activities for scheduling, curricula delivery and evaluations, which are required for program and institutional accreditation. These data provide information regarding potential primary and compensatory processes that affect the bodys acidbase buffering system. An introduction to acidbase disorders and interpretation of blood gases.
236 1243 130 806 861 478 120 780 82 542 1177 17 181 993 170 1222 514 384 630 766 1508 27 488 780 998 248 1177 1267 1384 952 1449 998 254 1145 95 1059 1485 1275 739 923